Obesity is a complex, chronic disease with escalating global prevalence, contributing significantly to a myriad of comorbidities including type 2 diabetes, cardiovascular disease, and certain cancers. Sustainable weight loss and long-term lifestyle modifications are crucial for effective management, yet traditional interventions often struggle with patient adherence and scalability. Personalized digital health coaching (PDHC), leveraging mobile technology and behavioral science, offers an innovative and accessible solution to provide continuous, tailored support, thereby empowering individuals to achieve and maintain healthier lifestyles and mitigate the profound health risks associated with obesity.
The aim of the study.
This study aimed to assess the effectiveness of a 12-month, mobile-app-delivered personalized digital health coaching (PDHC) program in achieving significant weight loss, increasing physical activity, and improving metabolic markers in adults with obesity compared to standard care.
Material and methods.
A prospective, unblinded, randomized controlled trial was conducted across three centers in Shanghai (China), Copenhagen (Denmark), and Tunis (Tunisia). A total of 380 adults with a Body Mass Index (BMI) ≥30 kg/m² were enrolled. Participants were randomized 1:1 to either the PDHC intervention group (n=190) or the control group (n=190). The intervention group participated in a 12-month PDHC program via a dedicated smartphone application. This program included weekly personalized virtual coaching sessions (video or chat) with a certified health coach, daily food logging with AI-driven feedback, goal-setting for physical activity, and access to educational resources. The control group received a single session of standard dietary and physical activity advice from a physician. Primary outcomes included the percentage of body weight loss from baseline at 12 months and change in objectively measured daily step count (via integrated smartphone pedometer). Secondary outcomes encompassed changes in blood pressure, fasting glucose, lipid profiles, and patient-reported quality of life (EQ-5D). Statistical analysis involved ANCOVA for continuous outcomes and chi-square tests for categorical outcomes, with significance set at p < 0.05.
At 12 months, the PDHC group achieved a significantly greater mean percentage of body weight loss (7.5% ± 2.0%) compared to the control group (2.1% ± 1.0%) (p < 0.001), with 35% of the PDHC group achieving ≥10% weight loss compared to only 8% in the control group (p < 0.001). Daily step count increased by an average of 4,800 steps/day (SD 1,200) in the PDHC group versus 800 steps/day (SD 350) in the control group (p < 0.001). Significant improvements in fasting glucose (-0.6 mmol/L vs. -0.1 mmol/L, p = 0.002) and triglyceride levels (-0.4 mmol/L vs. -0.1 mmol/L, p = 0.008) were also observed in the intervention group. Patient adherence to the coaching program was 78%. No serious adverse events were reported in either group.
Personalized digital health coaching is a highly effective, scalable, and patient-centric intervention for achieving significant and sustained weight loss and promoting positive lifestyle modifications in adults with obesity. The continuous, tailored support delivered via mobile technology empowers individuals to engage in and adhere to behaviors critical for obesity management, leading to improved anthropometric and metabolic outcomes. These findings strongly advocate for the integration of PDHC programs into evidence-based obesity treatment pathways, offering a viable solution to address this pervasive global health challenge.
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