Global Summit on Neuroscience & Brain Disorders 2026 · 2026-06-20 · Neurology

Blood-Brain Barrier Disruption Using Focused Ultrasound for Drug Delivery in Glioblastoma

Dr. Yuki Tanaka, Dr. Andrea Fischer
Tokyo University Hospital, Max Planck Institute

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Abstract

This phase II trial evaluated MRI-guided focused ultrasound for transient BBB opening to enhance temozolomide delivery in recurrent glioblastoma. FUS-enhanced delivery increased intratumoral drug concentration by 5.2-fold.

Keywords: focused ultrasound, blood-brain barrier, glioblastoma, drug delivery