5th International Conference on Cardiovascular Medicine & Heart Failure · 2026-05-15 · Cardiology

SGLT2 Inhibitors in Heart Failure with Preserved Ejection Fraction: A Meta-Analysis

Dr. Robert Chen, Dr. Maria Rodriguez, Dr. Wei-Liang Wu
Mayo Clinic, Cleveland Clinic

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Abstract

This meta-analysis of 8 RCTs (n=24,567) evaluates SGLT2 inhibitors in HFpEF patients. Empagliflozin and dapagliflozin reduced the composite endpoint of cardiovascular death or HF hospitalization by 21%.

Keywords: SGLT2 inhibitors, heart failure, HFpEF, meta-analysis